Changing how pain is managed with customized topical cream formulations.
Topical and transdermal creams and gels can be formulated to provide highly local concentrations at the site of application (e.g., NSAIDs for joint pain), for trigger point application (e.g., combinations of medications for neuropathic pain), or in a base that will allow systemic absorption. Side effects associated with oral administration can often be avoided when medications are used topically. Additionally, studies indicate there are no great restrictions on the type of drug that can be properly compounded into a transdermal gel.More..
In fact, compounded treatments may routinely include use of medications that possess pain-relieving properties including NMDA-receptor antagonists, such as dextromethorphan and ketamine which can block pain transmission in dorsal horn spinal neurons, reduce nociception, and decrease tolerance to and the need for opioid analgesics.